Cholera toxin-induced PGE2 activity is reduced by chemical reaction with l-histidine
نویسندگان
چکیده
منابع مشابه
Both cholera toxin-induced adenylate cyclase activation and cholera toxin biological activity are inhibited by antibodies against related synthetic peptides.
The immune response against six synthetic peptides corresponding to various segments of the B subunit of cholera toxin was evaluated. Conjugates in which the peptides were covalently linked to tetanus toxoid served for immunization of rabbits. As previously reported, four of these conjugates elicited antibodies cross-reactive with intact cholera toxin. We report here that antisera against two o...
متن کاملInhibition of cholera toxin-induced secretion by neuroleptics.
(1979) J . Physiol. 290, 367-386 Hughes, J. M., Murad, F., Chang, B. & Guerrant, R. L. (1978) Nature (London) 271, 755-756 Laburthe, M., Amiranoff, B. & Boissard, C. (1982) Biochem. Biophys. Acra 721, 101-108 Levens, N. R., Munday, K., Parsons, B., Poat, J. & Stewart, C. (1979) J. Physiol. (London) 286, 351-360 Mullan, N. A., Burgess, M. N. & Newsome, P. M. (1978) Infect. Immun. 19, 779-784 Mun...
متن کاملCholera toxin effects on body temperature changes induced by morphine.
The present study evaluates the influence of cholera toxin and its B-subunit on thermic responses to morphine in the rats. The holotoxin (1 microg/rat) and the B-subunit (5 microg) were administered ICV and three days later rats were challenged ICV with morphine and tested for changes of body temperature. Cholera toxin, but not its B-subunit, modified the time course of the hyperthermic respons...
متن کاملInhibition of E. coli L-Asparaginase by reaction with 2,3-butanedione. Chemical modification of arginine and histidine residues.
The inactivation of E. coli asparaginase by 2,3-butanedione studied with L-asparagine and diazooxonorvaline as substrates obeys pseudo first order kinetics. Activity losses are linear with respect to arginine and histidine modification, with complete inactivation being correlated with alteration of one arginine and one histidine per subunit. The rate of inactivation of the enzyme was reduced in...
متن کاملCholera Toxin Is Exported from Microsomes by the Sec61p Complex
After endocytosis cholera toxin is transported to the endoplasmic reticulum (ER), from where its A1 subunit (CTA1) is assumed to be transferred to the cytosol by an as-yet unknown mechanism. Here, export of CTA1 from the ER to the cytosol was investigated in a cell-free assay using either microsomes loaded with CTA1 by in vitro translation or reconstituted microsomes containing CTA1 purified fr...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
سال: 2001
ISSN: 0925-4439
DOI: 10.1016/s0925-4439(01)00052-7